Crown Coronation Study


To reduce the impact of COVID-19 on the health system, CROWN Coronation Study seeks to provide strategies to reduce exposure and mitigate disease, particularly amongst health care workers that are highly exposed to the virus.

Wits RHI’s Prof. Rees and Prof. Delany-Moretlwe are leading this study alongside Prof. Bruce Biccard, Prof. Linda-Gail Bekker and Dr Leon Du Toit (UCT) as part of a global effort.

Frontline health care workers are among the most highly exposed and strategies to protect them and preserve the health care system during this global crisis are urgently needed. These measures are being put in place while waiting for the vaccine to be fully developed.

Maintaining a healthy health care worker workforce is essential to success in our fight against SARS-CoV-2. In order to accomplish our aim, we will enrol up to +/-55 000 at-risk health workers in North America, Africa, Europe, Asia, and Australasia. Participants will be randomised to different weekly, twice weekly or daily doses of chloroquine, hydroxychloroquine or to placebo.

The benefit to participants in all study arms include education and intense surveillance. This study is rigorously designed and adequately powered to answer whether, and at what dose regimen, chloroquine prophylaxis is effective at mitigating the incidence or severity of symptomatic COVID-19.


Download Wits RHI’s Key responses to COVID-19